| United Nations (UN) | António Guterres (Secretary-General) | New York | — | UN Day – 24 Oct |
| UN General Assembly (UNGA) | Annalena Baerbock(80th) / Philémon Yang (79th PGA) | New York | — | UN Day – 24 Oct |
| UN Security Council (UNSC) | Rotational Presidency | New York | — | — |
| UN Economic & Social Council (ECOSOC) | - President (2025 Session/Current): H.E. Bob Rae (Canada).
- President-elect (2026 Session/Starts July 2025): H.E. Lok Bahadur Thapa (Nepal).
| New York | — | — |
| International Court of Justice (ICJ) | The current President (Chief) of the International Court of Justice (ICJ) is Judge Yuji Iwasawa from Japan, elected in March 2025 after the resignation of the previous president, Judge Nawaf SalamJoan E. Donoghue (President) | The Hague | — | — |
| UN Secretariat | António Guterres | New York | — | UN Day – 24 Oct |
| United Nations Development Programme (UNDP) | Alexander De Croo
| New York | — | World Development Information Day – 24 Oct |
| World Health Organization (WHO) | Dr Tedros Adhanom Ghebreyesus | Geneva | Healthy Beginnings, Hopeful Futures | World Health Day – 7 April |
| UNICEF | Catherine Russell | New York | — | World Children’s Day – 20 Nov |
| UNESCO | As of November 15, 2025, Khaled El-Enany of Egypt
| Paris | — | World Heritage Day – 18 April |
| FAO | Qu Dongyu | Rome | — | World Food Day – 16 Oct |
| International Labour Organization (ILO) | Gilbert F. Houngbo | Geneva | — | World Day for Safety & Health at Work – 28 April |
| International Monetary Fund (IMF) | Kristalina Georgieva | Washington DC | — | — |
| World Bank Group | Ajay Banga | Washington DC | — | — |
| UN Women | Sima Bahous | New York | For ALL Women and Girls: Rights. Equality. Empowerment | International Women’s Day – 8 March |
| UN Environment Programme (UNEP) | Inger Andersen | Nairobi | End Plastic Pollution | World Environment Day – 5 June |
| UN Refugee Agency (UNHCR) | Filippo Grandi / As of January 1, 2026, the UN High Commissioner for Refugees (UNHCR) is Barham Salih of Iraq. | Geneva | — | World Refugee Day – 20 June |
| World Food Programme (WFP) | Cindy McCain | Rome | — | World Food Day – 16 Oct |
| International Atomic Energy Agency (IAEA) | Rafael Grossi | Vienna | — | — |
| International Organization for Migration (IOM) | Amy Pope | Geneva | — | International Migrants Day – 18 Dec |
| UN Office on Drugs & Crime (UNODC) | Ghada Waly | Vienna | — | International Day against Drug Abuse – 26 June |
| UN Human Rights Council (OHCHR) | Volker Türk (UN High Commissioner) | Geneva | — | Human Rights Day – 10 Dec |
| International Telecommunication Union (ITU) | Doreen Bogdan-Martin | Geneva | — | World Telecommunication Day – 17 May |
| Universal Postal Union (UPU) | Masahiko Metoki | Bern | — | World Post Day – 9 Oct |
| International Maritime Organization (IMO) | Arsenio Dominguez | London | — | World Maritime Day – Sept (last Thu) |
| World Meteorological Organization (WMO) | Celeste Saulo | Geneva | — | World Meteorological Day – 23 March |
| International Civil Aviation Organization (ICAO) | Juan Carlos Salazar | Montreal | — | International Civil Aviation Day – 7 Dec |
| UN Habitat | Maimunah Mohd Sharif | Nairobi | Urban Crisis Response | World Habitat Day – 6 Oct 2025 |
| UN Peacekeeping | Jean-Pierre Lacroix | New York | — | International Day of UN Peacekeepers – 29 May |